Thank you for visiting our website.
We are moving to University College Dublin in 2024!
The Malone Lab is a transplantation research group. I am a Transplant Nephrologist and physician-scientist and have worked at Washington University at St Louis for 10 years. The WU kidney transplant program is one of the largest centers in the USA.
In the Malone lab, we focus primarily on the immune cell landscape in human kidney transplants. Our goal is to answer important clinical questions in transplantation by applying modern experimental techniques on human samples. We use single cell methods such as scRNA-seq, scATAC-seq, CITE-seq and immune cell profiling and use a mouse model of transplant rejection to complement our human studies. We perform all our own computational analyses in house. Kidney transplant diseases such as antibody mediated rejection and recurrent FSGS remain therapeutic challenges. We couple genetics and bioinformatics approaches to investigate how such diseases occur with a view to uncovering new markers of disease and treatment targets.
Our team was the first to publish on the application of single cell RNA-seq to single core kidney transplant biopsy samples.
We are now looking for new lab members. If you are interesting in working on single cell methods and computational analysis in transplant immunology please email or DM me: amalone@wustl.edu, @AndrewFMalone
Our work on investigating the transcriptional consequences of cell-cell physical interaction in human kidney transplant biopsies is out in @TransplantJrnl! Many thanks to the whole team, especially Aidan Leckie-Harre and Isabel Silverman. @WUTransplant https://journals.lww.com/transplantjournal/fulltext/9900/sequencing_of_physically_interacting_cells_in.526.aspx
This is our new design of visual abstracts at @NDTsocial. If you like, it please submit your best science to #NDT @vinckcaro @ERAkidney
Now in print! 📗
Single cell RNA-seq and functional assays to examine monocyte-endothelial cell interactions in CKD.
Transatlantic collaboration 🇮🇪🇺🇸 !!!
@sarahcormican91 @mattgriffinneph @uniofgalway @WUTransplant
We are looking for a fellow interested in training at one of the largest volume kidney transplant centers in the US with 5/5 outcomes scores. Please reach out for more info! @AndrewFMalone @TransplantPulse @anuja_java @massini_me @rohanspaul @KFlowyMD
Nice paper on snRNAseq from kidney transplants with fibrosis from @ValeriaMas11 and Colleagues 🔥